Abstract
A class of flavanoids exhibiting a high degree of selectivity for ERalpha over ERbeta has been discovered. The most active analogue 6 was found to be 66-fold ERalpha-selective and demonstrated uterine estradiol antagonism.
MeSH terms
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Animals
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Female
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Flavonoids / chemistry*
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Flavonoids / metabolism*
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Humans
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Protein Binding / physiology
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Rats
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Rats, Sprague-Dawley
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Receptors, Estrogen / metabolism*
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Stereoisomerism
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Uterus / metabolism
Substances
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Flavonoids
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Receptors, Estrogen